Schizophrenia Genome Project schizophrenia

The Schizophrenia Genome Project (S. Kingsmore, PI) was established in 2007 to identify the genetic basis of Schizophrenia. The SGP is a collaboration with Dr. Nora Bizzozero at the University of New Mexico (UNM) and Dr. Gary Schroth at Illumina Inc.

To date, the SGP has sequenced the transcriptome of 20 case and control samples, generating more than 15 billion nucleotides of sequence. Most of the samples analyzed to date have been from cerebellar cortex, an affected tissue in schizophrenia. Investigators are performing case–control comparisons to identify non–synonymous nucleotide variants that are associated with schizophrenia. The National Institutes of Mental Health has generously provided thousands of archived samples for validation studies.
Genomic Convergence Analysis of Schizophrenia
Alternative isoform regulation in human tissue transcriptomes