Medicago Hapmap

Medicago truncatula forms symbiotic interactions with nitrogen fixing bacteria and mycorrhizal fungi. In order to better understand the genes driving symbiosis as well as other important traits, we resequenced ~285 and identified variants in inbred lines spanning the range of Medicago diversity. In addition, we sequenced and de novo assembled 26 Medicago accessions as well as a mycorrhizal symbiont (Glomus versiforme) and 60 nitrogen-fixing rhizobial symbionts. The resulting sequences and variants allow from population genomic studies and connection of genotype to phenotype through genome-wide association studies (GWAS).

Publications

  • X. Sun, W. Chen, S. Ivanov, A. MacLean, H. Wight, T. Ramaraj, J. Mudge, M. Harrison and Z. Fei.
    Genome and evolution of the arbuscular mycorrhizal fungus Diversispora epigaea (formerly Glomus versiforme) and its bacterial endosymbionts
    New Phytologist (PMID: 30368822), 221(3), 1556--1573, 2019
    Medicago HapMap Project 
  • K. Moll, P. Zhou, T. Ramaraj, D. Fajardo, N. Devitt, M. Sadowsky, R. Stupar, P. Tiffin, J. Miller, N. Young, K. Silverstein and J. Mudge.
    Strategies for optimizing BioNano and Dovetail explored through a second reference quality assembly for the legume model, Medicago truncatula
    BMC Genomics (PMID: 28778149), 18(1), 2017
    Medicago HapMap Project 
  • J. Miller, P. Zhou, J. Mudge, J. Gurtowski, H. Lee, T. Ramaraj, B. Walenz, J. Liu, R. Stupar, R. Denny, L. Song, N. Singh, L. Maron, S. McCouch, W. McCombie, M. Schatz, P. Tiffin, N. Young and K. Silverstein.
    Hybrid assembly with long and short reads improves discovery of gene family expansions
    BMC Genomics (PMID: 28724409), 18(1), 2017
    Medicago HapMap Project 
  • P. Zhou, K. Silverstein, T. Ramaraj, J. Guhlin, R. Denny, J. Liu, A. Farmer, K. Steele, R. Stupar, J. Miller, P. Tiffin, J. Mudge and N. Young.
    Exploring structural variation and gene family architecture with De Novo assemblies of 15 Medicago genomes
    BMC Genomics (PMID: 28347275), 18(1), 2017
    Legume Federation  Medicago HapMap Project 
  • J. Yoder, R. Briskine, J. Mudge, A. Farmer, T. Paape, K. Steele, G. Weiblen, A. Bharti, P. Zhou, G. May, N. Young and P. Tiffin.
    Phylogenetic Signal Variation in the Genomes of Medicago (Fabaceae)
    Systematic Biology (PMID: 23417680), 62(3), 424--438, 2013
    Medicago HapMap Project 

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The National Center for Genome Resources is a not-for-profit research institute that innovates, collaborates, and educates in the field of genomic data science. As leaders in DNA sequence analysis, we partner with government, industry, and academia to drive biological discovery in all kingdoms of life. We deliver value through expertise in experimental design, software, computation, data integration and training a skilled workforce.

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